Tag Archives: Kidney

Another Chromophobe RCC :-)  

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Things to note :

  • well defined cell border
  • fluffy , moth-eaten cytoplasm
  • accentuation at the periphery
  • dark irregular nuclear membranes ( rasinoid)
  • inconspicuous nucleoli

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Renal Cell Carcinoma, Chromophobe Type “ChRCC”

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Hi there, few days ago i stumbled upon this relatively uncommon renal tumor and misdiagnosed it as Conventional renal cell carcinoma on smears. ” seams i got so much to learn ”

So lets review the Cytological Characteristics of this tumor :

  • polygonal cells.
  • well defined borders.
  • granular to light transparent cytoplasm, clear cells are rare.
  • accentuation of the granularity at the periphery of the cell.
  • central halo giving the cell koilocyte like appearance.
  • the nuclei are eccentric with anisonucleosis.
  • some of the nuclei are condensed with raisinoid appearance.

Beware of the Eosinophilic Variant of Chromophobe RCC as it very hard to differentiate from  Renal Oncocytoma which is a benign tumor.

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