Giant Cell Tumor Of Tendon Sheath, Aspirate

OLYMPUS DIGITAL CAMERA

GCTTS  is a very common Benign tumor usually affecting the digits  in females ( 2x more common) grossly it is a lobulated small (2-3 Cm.) yellowish mass.

Here in our case we can see :

  • osteoclast like gaint cells with many bland looking nuclei.
  • many mononuclear cells in the back ground.
  • Not much inflammatory cells or hemosidren.

The differential here:

  • pigmented villonodualr tenosynovitis – usually in large joints like knee with lots of hemosidren.
  • other granulomatous lesions – many inflammatory cells.

Pitfalls:

  • mononuclear cells stain with Desmin
  • you may see necrosis , tumor thrombi on paraffin sections.

Neoplastic vs reactive nature is still one of the questions to be solved.

 

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