Adrenal Cyst Aspirate , A Case of Pheochromocytoma

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  • The smears are hyper cellular.
  • cells appear singly or in loose groups or pseudo rosettes.
  • Three types of cell have been described:
  1.           The first type is small to moderate-sized polygonal cells with finely granular cytoplasm and uniform roundor oval nuclei with granular chromatin and prominent chromocenters. These cells are the prototypic cells of neuroendocrine tumors.
  2.            The second type is spindle cells with abundant cytoplasm, elongated nuclei, and coarse granular chromatin.
  3.            large, myoid-like cells with eccentric large nuclei, prominent nucleoli, and abundant pale, finely granular cytoplasm.

The smears may be composed of a mixture of these cell types or one cell type may predominate.   “M.BIBO 3rd ed”

Aspirating a pheochromocytoma is dangerous as it may precipitate a hypertensive crisis.

Remember the rule of 10% and multiple endocrine neoplasia association.

 

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